Leukocidin genes lukf-P83 and lukM are associated with Staphylococcus aureus clonal complexes 151, 479 and 133 isolated from bovine udder infections in Thuringia, Germany

نویسندگان

  • Katharina Schlotter
  • Ralf Ehricht
  • Helmut Hotzel
  • Stefan Monecke
  • Martin Pfeffer
  • Karsten Donat
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Leukocidin genes lukF-P83 and lukM are associated with taphylococcus aureus clonal complexes 151, 479 and 133 isolated from bovine udder infections in Thuringia, Germany

Staphylococcus aureus is one of the most important causal agents of bovine mastitis. Population studies on bovine Staphylococcus aureus isolates have identified considerable genetic heterogeneity among strains causing mastitis. The aim of this study was to investigate the contribution of different clonal complexes and the occurrence of virulence factors and resistance determinants within bovine...

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Microarray based study on virulence-associated genes and resistance determinants of Staphylococcus aureus isolates from cattle.

Staphylococcus aureus is a common pathogen which can colonise and infect not only man, but also domestic animals. Especially, infection of cattle is of high economic relevance as S. aureus is an important causal agent of bovine mastitis. In the present contribution, a DNA microarray was applied for the study of 144 different gene targets, including resistance genes and genes encoding exotoxins,...

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NoteGene of LukF - PV - like Component aureus P 83 is Linked with inkM of Panton - ValentineLeukocidin in Stuphyloco , ccus

presencc of two loci n thc strain A']'CC 497,7S. The first locus consisted of Aig2, tttkS. and fukF (First locus). The second one consistcd oi' tukS-PV and lukFLPV (Second iocus). In a previous study, we demonstrated the presencc of five components, I to V, in S. aureus P83 and identific:d components I, Itl, IV, ttnd V as LukF. LukM, LukS, and Hvll fbr leukocidin and T-ltemolysin, respectively....

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Comparison of genomic and antimicrobial resistance features of latex agglutination test-positive and latex agglutination test-negative Staphylococcus aureus isolates causing bovine mastitis.

The dairy industry suffers massive economic losses due to staphylococcal mastitis in cattle. The Staphaureux latex agglutination test (Oxoid, Basel, Switzerland) was reported to lead to negative results in 54% of bovine Staphylococcus aureus strains, and latex-negative strains are thought to be less virulent than Staphaurex latex-positive strains. However, comparative information on virulence a...

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Leucotoxic activities of Staphylococcus aureus strains isolated from cows, ewes, and goats with mastitis: importance of LukM/LukF'-PV leukotoxin.

Among the toxins that Staphylococcus aureus is able to secrete, bi-component toxins named leukotoxins target specifically leukocytes, mainly phagocytic cells. Isolates from cows, goats and ewes with mastitis were selected on the basis of the presence or not of the genes encoding the recently described LukM/LukF'-PV leukotoxin. Of the 128 isolates tested, 126 had moderate to high leukotoxic acti...

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تاریخ انتشار 2012